Sattar, N. and Taskinen, M.-R. (2013) Statins are diabetogenic – Myth or reality? Atherosclerosis Supplements, 13(1), pp. 1-10. (doi: 10.1016/j.atherosclerosissup.2012.06.001)
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Abstract
Multiple clinical trials have demonstrated the beneficial effects of statins in lowering levels of low-density lipoprotein and in the prevention of cardiovascular disease. However, although statins have a good safety profile, a debate has been ongoing as to whether use of statins increases risk of new-onset diabetes. Recent large scale meta-analyses of statin trials support the concept of a diabetogenic effect of statins, as do some other small trials assessing changes in glycaemia parameters and insulin levels. However, a definitive mechanism of action has not yet been elucidated. Nevertheless, the level of evidence has been sufficient to lead the FDA to make a change to the labelling of statins. This review assesses the current available evidence and offers a clinical perspective.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Sattar, Professor Naveed |
| Authors: | Sattar, N., and Taskinen, M.-R. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health |
| Journal Name: | Atherosclerosis Supplements |
| Publisher: | Elsevier |
| ISSN: | 1567-5688 |
| Published Online: | 19 July 2012 |
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