Complete genomic sequence of Ikoma Lyssavirus

Marston, D.A. et al. (2012) Complete genomic sequence of Ikoma Lyssavirus. Journal of Virology, 86(18), pp. 10242-10243. (doi: 10.1128/JVI.01628-12)

Abstract

Lyssaviruses (family Rhabdoviridae) constitute one of the most important groups of viral zoonoses globally. All lyssaviruses cause the disease rabies, an acute progressive encephalitis for which, once symptoms occur, there is no effective cure. Currently available vaccines are highly protective against the predominantly circulating lyssavirus species. Using next-generation sequencing technologies, we have obtained the whole-genome sequence for a novel lyssavirus, Ikoma lyssavirus (IKOV), isolated from an African civet in Tanzania displaying clinical signs of rabies. Genetically, this virus is the most divergent within the genus Lyssavirus. Characterization of the genome will help to improve our understanding of lyssavirus diversity and enable investigation into vaccine-induced immunity and protection.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Lembo, Dr Tiziana and Cleaveland, Professor Sarah
• Authors: Marston, D.A., Ellis, R., Horton, D.L., Kuzmin, I.V., Wise, E.L., McElhinney, L.M., Banyard, A.C., Ngeleja, C., Keyyu, J., Cleaveland, S., Lembo, T., Rupprecht, C.E., and Fooks, A.R.
• College/School: College of Medical Veterinary and Life Sciences > School of Biodiversity, One Health & Veterinary Medicine
• Journal Name: Journal of Virology
• Publisher: American Society for Microbiology
• ISSN: 0022-538X
• ISSN (Online): 1098-5514