Synthesis of the positron-emitting radiotracer [18F]-2-fluoro-2-deoxy-d-glucose from resin-bound perfluoroalkylsulfonates

Brown, L.J. et al. (2009) Synthesis of the positron-emitting radiotracer [18F]-2-fluoro-2-deoxy-d-glucose from resin-bound perfluoroalkylsulfonates. Organic and Biomolecular Chemistry, 7(3), p. 564. (doi: 10.1039/B816032E)

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Publisher's URL: http://dx.doi.org/10.1039/B816032E

Abstract

A new approach to the synthesis of 2-fluoro-2-deoxy-D-glucose (FDG, [<sup>19/18</sup>F]-3) is described, which employs supported perfluoroalkylsulfonate precursors 33–36, where the support consists of insoluble polystyrene resin beads. Treatment of these resins with [<sup>19</sup>F]fluoride ion afforded protected FDG [<sup>19</sup>F]-18 as the major product, and the identities of the main byproducts were determined. Acidic removal of the acetal protecting groups from [<sup>19</sup>F]-18 was shown to produce [<sup>19</sup>F]FDG. The method has been applied to the efficient radiosynthesis of the imaging agent [<sup>18</sup>F]FDG, and was shown to produce the radiochemical tracer in good radiochemical yield (average 73%, decay corrected).

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Champion, Dr Sue
Authors: Brown, L.J., Ma, N., Bouvet, D.R., Champion, S., Gibson, A.M., Hu, Y., Jackson, A., Khan, I., Millot, N., Topley, A.C., Wadsworth, H., Wynn, D., and Brown, R.C.D.
College/School:College of Medical Veterinary and Life Sciences > School of Psychology & Neuroscience
Journal Name:Organic and Biomolecular Chemistry
ISSN:1477-0520
ISSN (Online):1477-0539
Published Online:08 December 2008

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