Baker, R.H., Britton, C. , Roberts, B., Loer, C.M., Matthews, J.B. and Nisbet, A.J. (2012) Melanisation of teladorsagia circumcincta larvae exposed to sunlight: a role for GTP-Cyclohydrolase in nematode survival. International Journal for Parasitology, 42(10), pp. 887-891. (doi: 10.1016/j.ijpara.2012.06.005)
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Abstract
Pre-parasitic stage larvae of a number of parasitic nematodes express high levels of the enzyme GTP-Cyclohydrolase I (GTP-CH). C. elegans mutants which are GTP-CH deficient have low levels of cuticualr melanin and show increased sensitivity to anthelmintic drugs. Exposure of infective larvae of Teladorsagia circumcincta to sunlight leads to increased GTP-CH activity and melanin levels compared to unexposed larvae, suggesting that GTP-CH may protect against exposure to UV. The GTP-CH encoding gene from T. circumcincta was capable of rescuing the phenotype of C. elegans GTP-CH mutants, indicating a conserved role for this enzyme in melanisation.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Britton, Professor Collette |
Authors: | Baker, R.H., Britton, C., Roberts, B., Loer, C.M., Matthews, J.B., and Nisbet, A.J. |
College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity |
Journal Name: | International Journal for Parasitology |
ISSN: | 0020-7519 |
ISSN (Online): | 1879-0135 |
Published Online: | 01 August 2012 |
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