Altered excitation-contraction coupling in human chronic atrial fibrillation

Grandi, E., Workman, A.J. and Pandit, S.V. (2012) Altered excitation-contraction coupling in human chronic atrial fibrillation. Journal of Atrial Fibrillation, 2(10), pp. 1-17.

[img] Text


Publisher's URL:


This review focuses on the (mal)adaptive processes in atrial excitation-contraction coupling occurring in patients with chronic atrial fibrillation. Cellular remodeling includes shortening of the atrial action potential duration and effective refractory period, depressed intracellular Ca<sup>2+</sup> transient, and reduced myocyte contractility. Here we summarize the current knowledge of the ionic bases underlying these changes. Understanding the molecular mechanisms of excitation-contraction-coupling remodeling in the fibrillating human atria is important to identify new potential targets for AF therapy.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Workman, Dr Antony
Authors: Grandi, E., Workman, A.J., and Pandit, S.V.
College/School:College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health
Journal Name:Journal of Atrial Fibrillation
Copyright Holders:Copyright © 2012 The Authors
First Published:First published in Journal of Atrial Fibrillation 2(10):1-17
Publisher Policy:Reproduced in accordance with the copyright policy of the publisher
Related URLs:

University Staff: Request a correction | Enlighten Editors: Update this record