Sethu, S. and Melendez Romero, A. J. (2010) New developments on the TNFα-mediated signalling pathways. Bioscience Reports, 31(1), pp. 63-76. (doi: 10.1042/BSR20100040)
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Publisher's URL: http://dx.doi.org/10.1042/BSR20100040
Abstract
TNFα (tumour necrosis factor α) is an extensively studied pleiotropic cytokine associated with the pathogenesis of a variety of inflammatory diseases. It elicits a wide spectrum of cellular responses which mediates and regulates inflammation, immune response, cell survival, proliferation and apoptosis. TNFα initiates its responses by binding to its receptors. TNFα-induced effector responses are mediated by the actions and interactions among the various intracellular signalling mediators in the cell. TNFα induces both survival and apoptotic signal in a TRADD (TNF receptor-associated DD)-dependent and -independent way. The signals are further transduced via a variety of signalling mediators, including caspases, MAPKs (mitogen-activated protein kinases), phospholipid mediators and miRNA/miR (microRNA), whose roles in specific functional responses is not fully understood. Elucidating the complexity and cross talks among signalling mediators involved in the TNFα-mediated responses will certainly aid in the identification of molecular targets, which can potentially lead to the development of novel therapeutics to treat TNFα-associated disorders and in dampening inflammation.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Melendez Romero, Dr Alirio |
Authors: | Sethu, S., and Melendez Romero, A. J. |
College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity |
Journal Name: | Bioscience Reports |
Publisher: | Portland Press Ltd. |
ISSN: | 0144-8463 |
ISSN (Online): | 1573-4935 |
Published Online: | 21 October 2010 |
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