Intracranial delivery of stem cells

Muir, K.W. , Sinden, J., Miljan, E. and Dunn, L. (2011) Intracranial delivery of stem cells. Translational Stroke Research, 2(3), pp. 266-271. (doi:10.1007/s12975-011-0095-z)

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Publisher's URL: http://dx.doi.org/10.1007/s12975-011-0095-z

Abstract

The method of delivery of stem cells is a major factor to consider in the design of clinical trials of cell therapy. Different methods of delivery will be associated with different risks to the patient, and may also be associated with different potential for benefit. Current approaches are partly informed by the routes selected for study in animal models of focal ischaemia and CNS transplantation, but there has been little work comparing the efficacy of different routes of administration. Direct intraparenchymal delivery of cells has been employed in several preliminary clinical trials, and data on the safety of this approach are reviewed

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Muir, Professor Keith and Dunn, Mr Laurence
Authors: Muir, K.W., Sinden, J., Miljan, E., and Dunn, L.
College/School:College of Medical Veterinary and Life Sciences > Institute of Neuroscience and Psychology
College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
Journal Name:Translational Stroke Research
ISSN:1868-4483
ISSN (Online):1868-601X
Published Online:26 July 2011

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