Prospective study of the role of inflammation in renal cancer

Qayyum, T., McArdle, P.A., Lamb, G.W., Going, J.J., Horgan, P.G. , Oades, G., Aitchison, M.A. and Edwards, J. (2012) Prospective study of the role of inflammation in renal cancer. Urologia Internationalis, 88(3), pp. 277-281. (doi: 10.1159/000334971)

Abstract

<p><b>Background:</b> The local and systemic inflammatory responses provide prognostic information in cancer. The modified Glasgow Prognostic Score (mGPS) provides additional prognostic information than C-reactive protein (CRP) alone when assessing the systemic inflammation in cancer. The aim of this study was to determine the role of local and systemic inflammation in renal cancer.</p> <p><b>Methods:</b> The cohort consisted of 79 patients who had undergone potential curative resection. Systemic inflammation, mGPS, was constructed by measuring preoperative CRP and albumin concentrations and the Klintrup-Makinen score was evaluated histologically for the local inflammatory response. Pathological parameters such as T stage, grade and tumour necrosis were also assessed. The local inflammatory response was assessed by examining all inflammatory cells at the tumour edge on diagnostic haematoxylin and eosin slides.</p> <p><b>Results:</b> On univariate analysis, T stage (p < 0.001), grade (p = 0.044) and mGPS (p < 0.001) were significant predictors of cancer-specific survival. On multivariate analysis, mGPS (hazard ratio 8.64, 95% confidence interval 3.5–21.29, p < 0.001) was the only significant independent predictor of cancer-specific survival.</p> <p><b>Conclusion:</b> A preoperative systemic inflammatory response as measured by the mGPS is an independent predictor of poor cancer-specific survival in renal cancer in patients undergoing potential curative resection.</p>

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Horgan, Professor Paul and Aitchison, Mr Michael and Edwards, Professor Joanne and Qayyum, Dr Tahir
• Authors: Qayyum, T., McArdle, P.A., Lamb, G.W., Going, J.J., Horgan, P.G., Oades, G., Aitchison, M.A., and Edwards, J.
• College/School: College of Medical Veterinary and Life Sciences > School of Cancer Sciences; College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing; College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing > Clinical Specialities
• Journal Name: Urologia Internationalis
• ISSN: 0042-1138
• Published Online: 23 February 2012