Mitochondrial pharmacology

Smith, R.A.J., Hartley, R.C. , Cochemé, H.M. and Murphy, M.P. (2012) Mitochondrial pharmacology. Trends in Pharmacological Sciences, 33(6), pp. 341-352. (doi:10.1016/j.tips.2012.03.010) (PMID:22521106)

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Abstract

Mitochondria are being recognized as key factors in many unexpected areas of biomedical science. In addition to their well-known roles in oxidative phosphorylation and metabolism, it is now clear that mitochondria are also central to cell death, neoplasia, cell differentiation, the innate immune system, oxygen and hypoxia sensing, and calcium metabolism. Disruption to these processes contributes to a range of human pathologies, making mitochondria a potentially important, but currently seemingly neglected, therapeutic target. Mitochondrial dysfunction is often associated with oxidative damage, calcium dyshomeostasis, defective ATP synthesis, or induction of the permeability transition pore. Consequently, therapies designed to prevent these types of damage are beneficial and can be used to treat many diverse and apparently unrelated indications. Here we outline the biological properties that make mitochondria important determinants of health and disease, and describe the pharmacological strategies being developed to address mitochondrial dysfunction.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Hartley, Professor Richard
Authors: Smith, R.A.J., Hartley, R.C., Cochemé, H.M., and Murphy, M.P.
College/School:College of Science and Engineering > School of Chemistry
Journal Name:Trends in Pharmacological Sciences
Publisher:Elsevier
ISSN:0165-6147
ISSN (Online):1873-3735
Published Online:18 April 2012
Copyright Holders:Copyright © 2012 Elsevier Ltd.
First Published:First published in Trends in Pharmacological Sciences 33(6):341-352
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
553931Developing chemical mass spectrometry probes to assess the production of reactive oxygen species in vivoRichard HartleyBiotechnology and Biological Sciences Research Council (BBSRC)BB/I012826/1CHEM - CHEMISTRY