Lack of inhibitory effect of cimetidine on caffeine metabolism in children using the caffeine breath test

Parker, A.C., Pritchard, P., Preston, T. , Dalzell, A.M. and Choonara, I. (1997) Lack of inhibitory effect of cimetidine on caffeine metabolism in children using the caffeine breath test. British Journal of Clinical Pharmacology, 43(5), pp. 467-470. (doi: 10.1046/j.1365-2125.1997.00589.x)

Abstract

<b>Aims</b> To study the potential drug interaction between cimetidine and caffeine in a group of children who received cimetidine for gastritis.<p></p> <b>Methods</b> The caffeine breath test was carried out prior to the administration of cimetidine and after 2–3 weeks therapy. The children (n=1) received 300–800 mg cimetidine daily (11–36 mg kg−1 day−1 ).<p></p> <b>Results</b> There was no significant change in the 2 h cumulative labelled CO2 following the administration of cimetidine (mean values 5.61% before and 4.87% during cimetidine; Student’s t-test P>0.2).<p></p> <b>Conclusions</b> Cimetidine did not have an inhibitory effect on the metabolism of caffeine in this group of children studied.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Preston, Professor Tom
• Authors: Parker, A.C., Pritchard, P., Preston, T., Dalzell, A.M., and Choonara, I.
• College/School: College of Science and Engineering > Scottish Universities Environmental Research Centre
• Journal Name: British Journal of Clinical Pharmacology
• Journal Abbr.: Br. J. Clin. Pharmacol.
• ISSN: 0306-5251
• ISSN (Online): 1365-2125