Fibrinogen and its degradation products as thrombotic risk factors

Lowe, G.D.O. and Rumley, A. (2001) Fibrinogen and its degradation products as thrombotic risk factors. Annals of the New York Academy of Sciences, 936, pp. 560-565.

Abstract

Recent meta-analyses of prospective studies have shown that plasma levels of both fibrinogen and fibrin D-dimer are independent predictors of ischemic heart disease. Although at present reported studies using different assays do not show heterogeneity, there is a need for prospective comparison of different assays, as well as for development of standards. Collaborative development of the clinical use of these risk predictors is also required. Finally, the causal significance of the associations of fibrinogen and D-dimer with thrombotic events remains to be established by randomized controlled trials of reduction in their plasma levels.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Rumley, Dr Ann and Lowe, Professor Gordon
• Authors: Lowe, G.D.O., and Rumley, A.
• Subjects: R Medicine > RC Internal medicine; Q Science > QP Physiology
• College/School: College of Medical Veterinary and Life Sciences; College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health
• Journal Name: Annals of the New York Academy of Sciences
• Publisher: New York Academy of Sciences
• ISSN: 0077-8923
• Copyright Holders: ©2001 by the New York Academy of Sciences.
• First Published: First published in Annals of the New York Academy of Sciences 936:560-565
• Publisher Policy: Reprinted by permission of the New York Academy of Sciences from the Annals of the New York Academy of Sciences