Human papillomavirus gene expression is controlled by host cell splicing factors

Klymenko, T. and Graham, S. (2012) Human papillomavirus gene expression is controlled by host cell splicing factors. Biochemical Society Transactions, 40, pp. 773-777. (doi: 10.1042/BST20120079) (PMID:22817732)

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Abstract

Human papillomaviruses (HPV) infect stratified epithelia and cause a variety of lesions ranging from benign warts to invasive tumours. The virus life cycle is tightly linked to differentiation of the keratinocyte it infects: papillomaviruses modulate host gene expression to ensure efficient virus replication. For example, the viral transcription factor E2 can directly upregulate, in an epithelial differentiation-dependent manner, cellular SR (serine/arginine-rich) splicing factors that control constitutive and alternative splicing. Changes in alternative splicing and the mechanisms controlling this for viral mRNAs have been a subject to intense exploration. However, to date experiments have only been carried out in model systems because the genetic systems suitable for studying alternative splicing of viral RNAs in the context of the virus life cycle are relatively recent and technically challenging. Now using these life cycle-supporting systems, our laboratory has identified SR proteins as important players in differentiation-dependent regulation of HPV gene expression. Better understanding of the role of cellular factors in regulating the virus life cycle is needed as it may help development of novel diagnostic approaches and antiviral therapies in the future.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Graham, Professor Sheila and Klymenko, Dr Tetyana
Authors: Klymenko, T., and Graham, S.
Subjects:Q Science > QR Microbiology > QR355 Virology
College/School:College of Medical Veterinary and Life Sciences > School of Infection & Immunity
College of Medical Veterinary and Life Sciences > School of Infection & Immunity > Centre for Virus Research
Journal Name:Biochemical Society Transactions
Journal Abbr.:Biochem. Soc. Trans.
Publisher:Portland Press
ISSN:0300-5127
ISSN (Online):1470-8752

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
507841Human papillomavirus E2 regulation of splicing factors: consequences for the virus life cycleSheila GrahamWellcome Trust (WELLCOME)088848/Z/09/ZCentre for Virus Research