Li, Y., Breitling, R. and Jansen, R.C. (2008) Generalizing genetical genomics: getting added value from environmental perturbation. Trends in Genetics, 24(10), pp. 518-524. (doi: 10.1016/j.tig.2008.08.001)
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Publisher's URL: http://dx.doi.org/10.1016/j.tig.2008.08.001
Abstract
Genetical genomics is a useful approach for studying the effect of genetic perturbations on biological systems at the molecular level. However, molecular networks depend on the environmental conditions and, thus, a comprehensive understanding of biological systems requires studying them across multiple environments. We propose a generalization of genetical genomics, which combines genetic and sensibly chosen environmental perturbations, to study the plasticity of molecular networks. This strategy forms a crucial step toward understanding why individuals respond differently to drugs, toxins, pathogens, nutrients and other environmental influences. Here we outline a strategy for selecting and allocating individuals to particular treatments, and we discuss the promises and pitfalls of the generalized genetical genomics approach.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Breitling, Professor Rainer |
| Authors: | Li, Y., Breitling, R., and Jansen, R.C. |
| Subjects: | Q Science > QH Natural history > QH426 Genetics |
| College/School: | College of Medical Veterinary and Life Sciences > School of Molecular Biosciences |
| Journal Name: | Trends in Genetics |
| ISSN: | 0168-9525 |
| Published Online: | 04 September 2008 |
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