Genetic variation at CHRNA5-CHRNA3-CHRNB4 interacts with smoking status to influence body mass index

Freathy, R.M. et al. (2011) Genetic variation at CHRNA5-CHRNA3-CHRNB4 interacts with smoking status to influence body mass index. International Journal of Epidemiology, 40(6), pp. 1617-28. (doi: 10.1093/ije/dyr077)

Abstract

<p><b>Background:</b> Cigarette smoking is associated with lower body mass index (BMI), and a commonly cited reason for unwillingness to quit smoking is a concern about weight gain. Common variation in the CHRNA5-CHRNA3-CHRNB4 gene region (chromosome 15q25) is robustly associated with smoking quantity in smokers, but its association with BMI is unknown. We hypothesized that genotype would accurately reflect smoking exposure and that, if smoking were causally related to weight, it would be associated with BMI in smokers, but not in never smokers.</p>

• Item Type: Articles
• Additional Information: This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.5), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Davey Smith, Prof George and Watt, Professor Graham and Johnson, Dr Paul and Padmanabhan, Professor Sandosh and Sattar, Professor Naveed
• Authors: Freathy, R.M., Kazeem, G.B., Morris, R.W., Johnson, P.C.D., Paternoster, L., Ebrahim, S., Hattersley, A.T., Hill, A., Hingorani, A.D., Holst, C., Jefferis, B.J., Kring, S., Mooser, V., Padmanabhan, S., Preisig, M., Ring, S.M., Sattar, N., Upton, M.N., Vollenweider, P., Waeber, G., Sorensen, T.I.A., Frayling, T.M., Watt, G., Lawlor, D.A., Whincup, P.H., Tozzi, F., Davey Smith, G., and Munafo, M.
• College/School: College of Medical Veterinary and Life Sciences > School of Health & Wellbeing > General Practice and Primary Care; College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health
• Journal Name: International Journal of Epidemiology
• Publisher: Oxford University Press
• ISSN: 0300-5771
• ISSN (Online): 1464-3685
• Published Online: 18 May 2011
• Copyright Holders: This work is licensed under a Creative Commons Attribution-Noncommercial- No Derivative Works 3.0 United States License.
• First Published: First published in International Journal of Epidemiology 2011 40(6):1617-1628
• Publisher Policy: Reproduced in accordance with the copyright policy of the publisher