Stangherlin, A. and Zaccolo, M. (2012) Phosphodiesterases and subcellular compartmentalized cAMP signaling in the cardiovascular system. American Journal of Physiology: Heart and Circulatory Physiology, 302(2), H379-H390. (doi: 10.1152/ajpheart.00766.2011)
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Publisher's URL: http://dx.doi.org/10.1152/ajpheart.00766.2011
Abstract
Phosphodiesterases are key enzymes in the cAMP signaling cascade. They convert cAMP in its inactive form 5′-AMP and critically regulate the intensity and the duration of cAMP-mediated signals. Multiple isoforms exist that possess different intracellular distributions, different affinities for cAMP, and different catalytic and regulatory properties. This complex repertoire of enzymes provides a multiplicity of ways to modulate cAMP levels, to integrate more signaling pathways, and to respond to the specific needs of the cell within distinct subcellular domains. In this review we summarize key findings on phosphodiesterase compartmentalization in the cardiovascular system.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Zaccolo, Professor Manuela and Stangherlin, Dr Alessandra |
| Authors: | Stangherlin, A., and Zaccolo, M. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Psychology & Neuroscience College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing |
| Journal Name: | American Journal of Physiology: Heart and Circulatory Physiology |
| Journal Abbr.: | AJP: Heart and circulatory physiology |
| ISSN: | 0363-6135 |
| ISSN (Online): | 1522-1539 |
| Published Online: | 28 October 2011 |
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