Protheroe, R.E. et al. (2012) The clinical features and outcome of 2009 H1N1 influenza infection in allo-SCT patients: a British Society of Blood and Marrow Transplantation study. Bone Marrow Transplantation, 47(1), pp. 88-94. (doi: 10.1038/bmt.2011.12)
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Publisher's URL: http://dx.doi.org/10.1038/bmt.2011.12
Abstract
The clinical course of 2009 H1N1 influenza in Allo-SCT patients is unknown. Data were collected in the UK from October 2009 to April 2010 on laboratory-confirmed cases of H1N1 influenza in Allo-SCT recipients. H1N1 infection was diagnosed in 60 patients, median age 42 years, at a median of 10 months post-SCT. Twenty-one patients (35%) developed pneumonia and nine (15%) required admission to intensive care units. Actuarial mortality was 7% at 28 days and 19% 4 months post-diagnosis of 2009 H1N1 influenza. Increasing age and pre-existing lung disease were risk factors for pneumonia (P=0.006 and 0.037, respectively); older age was a risk factor for death (P=0.012). Morbidity and mortality from 2009 H1N1 influenza in SCT patients exceeds that of immunocompetent patients, but parallels that in other critically ill hospitalised cohorts; the elderly and those with chronic pulmonary disease are at greatest risk.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | McQuaker, Dr Grant |
| Authors: | Protheroe, R.E., Kirkland, K.E., Pearce, R.M., Kaminaris, K., Bloor, A., Potter, M.N., Nagra, S., Gilleece, M.H., McQuaker, I.G., Jackson, G., Cook, G., and Marks, D.I. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing |
| Journal Name: | Bone Marrow Transplantation |
| ISSN: | 0268-3369 |
| ISSN (Online): | 1476-5365 |
| Published Online: | 28 February 2011 |
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