McColl, K.E.L. (2012) Serum IGF-1 linking visceral obesity with esophageal adenocarcinoma: unconvincing evidence. American Journal of Gastroenterology, 107(2), pp. 205-206. (doi: 10.1038/ajg.2011.421)
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Abstract
There is a strong positive association between body mass index (BMI) and risk of esophageal adenocarcinoma. This is likely to be largely or entirely explained by the established association between central obesity and gastroesophageal reflux and between the latter and risk of esophageal adenocarcinoma. Visceral fat is also metabolically active and there is interest in the possibility that humoral factors released by this fat might promote esophageal carcinogenesis. Insulin growth factor I (IGF-1) has been studied but current data do not support circulating total IGF-1 as a humoral factor linking BMI and esophageal carcinogenesis.
| Item Type: | Articles (Editorial) |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | McColl, Professor Kenneth |
| Authors: | McColl, K.E.L. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health |
| Journal Name: | American Journal of Gastroenterology |
| ISSN: | 0002-9270 |
| ISSN (Online): | 1572-0241 |
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