Systematic review of perfusion imaging with computed tomography and magnetic resonance in acute ischemic stroke: heterogeneity of acquisition and postprocessing parameters: a translational medicine research collaboration multicentre acute stroke imaging study

Dani, K.A., Thomas, R.G.R., Chappell, F.M., Shuler, K., Muir, K.W. and Wardlaw, J.M. (2012) Systematic review of perfusion imaging with computed tomography and magnetic resonance in acute ischemic stroke: heterogeneity of acquisition and postprocessing parameters: a translational medicine research collaboration multicentre acute stroke imaging study. Stroke, 43(2), pp. 563-566. (doi:10.1161/STROKEAHA.111.629923)

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Publisher's URL: http://dx.doi.org/10.1161/STROKEAHA.111.629923

Abstract

<b>Background and Purpose</b>-Heterogeneity of acquisition and postprocessing parameters for magnetic resonance– and computed tomography–based perfusion imaging in acute stroke may limit comparisons between studies, but the current degree of heterogeneity in the literature has not been precisely defined.<p></p> <b>Methods</b>-We examined articles published before August 30, 2009 that reported perfusion thresholds, average lesion perfusion values, or correlations of perfusion deficit volumes from acute stroke patients <24 hours postictus. We compared acquisition parameters from published studies with guidance from the Acute Stroke Imaging Research Roadmap1. In addition, we assessed the consistency of postprocessing parameters.<p></p> <b>Results</b>-Twenty computed tomography perfusion and 49 perfusion-weighted imaging studies were included from 7152 articles. Although certain parameters were reported frequently, consistently, and in line with the Roadmap proposals, we found substantial heterogeneity in other parameters, and there was considerable variation and underreporting of postprocessing methodology.<p></p> <b>Conclusions</b>-There is substantial scope to increase homogeneity in future studies, eg, through reporting standards.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Muir, Professor Keith and Dani, Dr Krishna
Authors: Dani, K.A., Thomas, R.G.R., Chappell, F.M., Shuler, K., Muir, K.W., and Wardlaw, J.M.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
College of Medical Veterinary and Life Sciences > Institute of Neuroscience and Psychology
Journal Name:Stroke
ISSN:0039-2499
ISSN (Online):1524-4628
Published Online:13 October 2011

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