Functional proteomics to dissect tyrosine kinase signalling pathways in cancer

Kolch, W. and Pitt, A. (2010) Functional proteomics to dissect tyrosine kinase signalling pathways in cancer. Nature Reviews Cancer, 10(9), pp. 618-629. (doi: 10.1038/nrc2900) (PMID:20720570)

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Advances in the generation and interpretation of proteomics data have spurred a transition from focusing on protein identification to functional analysis. Here we review recent proteomics results that have elucidated new aspects of the roles and regulation of signal transduction pathways in cancer using the epidermal growth factor receptor (EGFR), ERK and breakpoint cluster region (BCR)-ABL1 networks as examples. The emerging theme is to understand cancer signalling as networks of multiprotein machines which process information in a highly dynamic environment that is shaped by changing protein interactions and post-translational modifications (PTMs). Cancerous genetic mutations derange these protein networks in complex ways that are tractable by proteomics.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Kolch, Prof Walter and Pitt, Dr Andrew
Authors: Kolch, W., and Pitt, A.
College/School:College of Medical Veterinary and Life Sciences > School of Molecular Biosciences
Journal Name:Nature Reviews Cancer
ISSN (Online):1474-1768

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
387191Radical Solutions for Researching the Proteome (RASOR)Andrew PittBiotechnology and Biological Sciences Research Council (BBSRC)BB/C511572/1Institute of Molecular Cell and Systems Biology