Syme, C.D. , Martino, C., Yusvana, R., Sirimuthu, N.M.S. and Cooper, J.M. (2012) Quantitative characterization of individual microdroplets using surface-enhanced resonance Raman scattering spectroscopy. Analytical Chemistry, 84(3), pp. 1491-1495. (doi: 10.1021/ac202705a)
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Abstract
Surface-enhanced resonance Raman scattering (SERRS) spectroscopy is a highly sensitive optical technique capable of detecting multiple analytes rapidly and simultaneously. There is significant interest in SERRS detection in micro- and nanotechnologies, as it can be used to detect extremely low analyte concentrations in small volumes of fluids, particularly in microfluidic systems. There is also rapidly growing interest in the field of microdroplets, which promises to offer the analyst many potential advantages over existing technologies for both design and control of microfluidic assays. While there have been rapid advances in both fields in recent years, the literature on SERRS-based detection of individual microdroplets remains lacking. In this paper, we demonstrate the ability to quantitatively detect multiple variable analyte concentrations from within individual microdroplets in real time using SERRS spectroscopy. We also demonstrate the use of a programmable pump control algorithm to generate concentration gradients across a chain of droplets.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Narayana Mudalige Sathkumara, Dr Siri and Syme, Dr Christopher and Cooper, Professor Jonathan |
| Authors: | Syme, C.D., Martino, C., Yusvana, R., Sirimuthu, N.M.S., and Cooper, J.M. |
| College/School: | College of Science and Engineering > School of Engineering > Biomedical Engineering |
| Journal Name: | Analytical Chemistry |
| ISSN: | 0003-2700 |
| Published Online: | 16 December 2011 |
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