Hale, B.G. , Albrecht, R.A. and García-Sastre, A. (2010) Innate immune evasion strategies of influenza viruses. Future Microbiology, 5(1), pp. 23-41. (doi: 10.2217/fmb.09.108)
Full text not currently available from Enlighten.
Abstract
Influenza viruses are globally important human respiratory pathogens. These viruses cause seasonal epidemics and occasional worldwide pandemics, both of which can vary significantly in disease severity. The virulence of a particular influenza virus strain is partly determined by its success in circumventing the host immune response. This article briefly reviews the innate mechanisms that host cells have evolved to resist virus infection, and outlines the plethora of strategies that influenza viruses have developed in order to counteract such powerful defences. The molecular details of this virus-host interplay are summarized, and the ways in which research in this area is being applied to the rational design of protective vaccines and novel antivirals are discussed.
| Item Type: | Articles |
|---|---|
| Keywords: | Influenza |
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Hale, Dr Benjamin |
| Authors: | Hale, B.G., Albrecht, R.A., and García-Sastre, A. |
| Subjects: | Q Science > Q Science (General) Q Science > QH Natural history > QH345 Biochemistry Q Science > QR Microbiology > QR355 Virology |
| College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity |
| Journal Name: | Future Microbiology |
| ISSN: | 1746-0913 |
| Related URLs: |
University Staff: Request a correction | Enlighten Editors: Update this record
Deposit and Record Details
Deposit and Record Details