Hale, B.G. and Randall, R.E. (2007) PI3K signalling during influenza A virus infections. Biochemical Society Transactions, 35(2), pp. 186-187. (doi: 10.1042/BST0350186)
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Abstract
Recent work has demonstrated that the PI3K (phosphoinositide 3-kinase) signalling pathway is important for efficient influenza A virus replication. Activation of PI3K in virus-infected cells is mediated by the viral NS1 protein, which binds directly to the p85beta regulatory subunit of PI3K and causes the PI3K-dependent phosphorylation of Akt (protein kinase B). Given that recombinant influenza A viruses unable to activate PI3K signalling are attenuated in tissue culture, the PI3K pathway could be a novel target for the development of future anti-influenza drugs.
| Item Type: | Articles |
|---|---|
| Keywords: | Influenza |
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Hale, Dr Benjamin |
| Authors: | Hale, B.G., and Randall, R.E. |
| Subjects: | Q Science > Q Science (General) Q Science > QH Natural history > QH345 Biochemistry Q Science > QR Microbiology > QR355 Virology |
| College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity |
| Journal Name: | Biochemical Society Transactions |
| ISSN: | 0300-5127 |
| Published Online: | 20 March 2007 |
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