The relationship between weight loss and interleukin 6 in non-small-cell lung cancer

Scot, H.R., McMillan, D.C. , Crilly, A., McArdl, C.S. and Milroy, R. (1996) The relationship between weight loss and interleukin 6 in non-small-cell lung cancer. British Journal of Cancer, 73(12), pp. 1560-1562. (doi: 10.1038/bjc.1996.294)

Abstract

Markers of the inflammatory response, interleukin 6, C-reactive protein, albumin and full blood count, were measured in non-small-cell lung cancer (NSCLC) patients (n = 21) with and without weight loss ( > 5%). There were significant increases in circulating C-reactive protein (P < 0.001), interleukin 6 (P < 0.01) and platelets (P < 0.01) in the weight-losing group. Moreover, there was a statistically significant correlation (r = 0.785, P < 0.001) between interleukin 6 and C-reactive protein concentrations. These results are consistent with interleukin 6 and the acute phase response promoting weight loss in NSCLC.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: McMillan, Professor Donald
• Authors: Scot, H.R., McMillan, D.C., Crilly, A., McArdl, C.S., and Milroy, R.
• College/School: College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
• Journal Name: British Journal of Cancer
• Journal Abbr.: Br. J. Cancer
• ISSN: 0007-0920
• ISSN (Online): 1532-1827