The cholinergic regulation of potassium (86Rb ) permeability in sweat glands isolated from patients with cystic fibrosis

Wilson, S.M., Pediani, J. , Cockburn, F., Bovell, D.L., Jenkinson, D.M., Paton, J.Y. , Coutts, J., Davidson, R., Lambert, J. and Morris, G. (1991) The cholinergic regulation of potassium (86Rb ) permeability in sweat glands isolated from patients with cystic fibrosis. Experimental Physiology, 76(4), pp. 573-578.

Abstract

Sweat glands isolated from skin obtained from normal subjects and patients with cystic fibrosis (CF) were pre-loaded with 86Rb+ and superfused with a physiological salt solution and the rate of 86Rb+ efflux was measured as an indicator of cellular potassium permeability. Acetylcholine always evoked a permeability increase in the glands from control subjects and this response could be resolved into calcium-dependent and calcium-independent components. Sweat glands from CF patients did not show such consistent responses. In three individuals the glands were abnormally insensitive to acetylcholine but normal responsiveness was seen in a fourth case. It is proposed that CF can induce dysfunction of calcium-dependent control processes in sweat glands.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Pediani, Dr John and Paton, Dr James and Bovell, Mrs Margherita
• Authors: Wilson, S.M., Pediani, J., Cockburn, F., Bovell, D.L., Jenkinson, D.M., Paton, J.Y., Coutts, J., Davidson, R., Lambert, J., and Morris, G.
• College/School: College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing > Clinical Specialities
• Journal Name: Experimental Physiology
• Journal Abbr.: Exp. Physiol.
• ISSN: 0958-0670
• ISSN (Online): 1469-445X