Currie, G. , Freel, E. M., Perry, C. G. and Dominiczak, A. F. (2012) Disorders of blood pressure regulation — role of catecholamine biosynthesis, release, and metabolism. Current Hypertension Reports, 14(1), pp. 38-45. (doi: 10.1007/s11906-011-0239-2)
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Publisher's URL: http://dx.doi.org/10.1007/s11906-011-0239-2
Abstract
Catecholamines (epinephrine and norepinephrine) are synthesised and produced by the adrenal medulla and postganglionic nerve fibres of the sympathetic nervous system. It is known that essential hypertension has a significant neurogenic component, with the rise in blood pressure mediated at least in part by overactivity of the sympathetic nervous system. Moreover, novel therapeutic strategies aimed at reducing sympathetic activity show promise in the treatment of hypertension. This article reviews recent advances within this rapidly changing field, particularly focusing on the role of genetic polymorphisms within key catecholamine biosynthetic enzymes, cofactors, and storage molecules. In addition, mechanisms linking the sympathetic nervous system and other adverse cardiovascular states (obesity, insulin resistance, dyslipidaemia) are discussed, along with speculation as to how recent scientific advances may lead to the emergence of novel antihypertensive treatments.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Currie, Dr Gemma and Freel, Dr Marie and Perry, Dr Colin and Dominiczak, Professor Anna |
| Authors: | Currie, G., Freel, E. M., Perry, C. G., and Dominiczak, A. F. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing |
| Journal Name: | Current Hypertension Reports |
| Publisher: | Springer Healthcare |
| ISSN: | 1522-6417 |
| ISSN (Online): | 1534-3111 |
| Published Online: | 09 November 2011 |
| Related URLs: |
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