Abnormal control of ventilation in adolescents with myelodysplasia

Swaminathan, S., Paton, J.Y. , Ward, S.L., Jacobs, R.A., Sargent, C.W. and Keens, T.G. (1989) Abnormal control of ventilation in adolescents with myelodysplasia. Journal of Pediatrics, 115(6), pp. 898-903.

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Infants with myelomeningocele have abnormalities in ventilatory control. To determine whether these persist into later life, we studied 14 patients with myelomeningocele and Arnold-Chiari malformation (age 18.0 +/- 0.8 (SE) years), and compared them with 14 control subjects (age 24.0 +/- 0.9 years). Pulmonary function and ventilatory muscle strength did not differ between patients with myelomeningocele and control subjects. Hypercapnic ventilatory responses were significantly lower in the group with myelomeningocele (1.98 L/min/mm Hg) compared with control values (3.33 L/min/mm Hg; p less than 0.01). Hypoxic ventilatory responses (-1.4 L/min/%oxygen saturation of hemoglobin in arterial blood) were not significantly different from control values (-2.14 L/min/%oxygen saturation). In control subjects the hypercapnic and hypoxic ventilatory responses were highly correlated with each other within subjects (r = 0.84; p less than 0.002) but not in those with myelomeningocele (r = 0.34; not significant). We concluded that adolescents and young adults with myelomeningocele have abnormalities in control of ventilation during sleep and wakefulness. We speculate that the Arnold-Chiari malformation interferes with central chemosensitivity (hypercapnic ventilatory response) and central integration of chemoreceptor output.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Paton, Dr James
Authors: Swaminathan, S., Paton, J.Y., Ward, S.L., Jacobs, R.A., Sargent, C.W., and Keens, T.G.
College/School:College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing > Clinical Specialities
Journal Name:Journal of Pediatrics
Journal Abbr.:J Pediatr.
ISSN (Online):1097-6833
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