The prevalences of Salmonella Genomic Island 1 variants in human and animal Salmonella Typhimurium DT104 are distinguishable using a Bayesian approach

Mather, A.E., Denwood, M.J., Haydon, D.T. , Matthews, L. , Mellor, D.J. , Coia, J.E., Brown, D.J. and Reid, S.W.J. (2011) The prevalences of Salmonella Genomic Island 1 variants in human and animal Salmonella Typhimurium DT104 are distinguishable using a Bayesian approach. PLoS ONE, 6(11), e27220. (doi: 10.1371/journal.pone.0027220)

Abstract

Throughout the 1990s, there was an epidemic of multidrug resistant Salmonella Typhimurium DT104 in both animals and humans in Scotland. The use of antimicrobials in agriculture is often cited as a major source of antimicrobial resistance in pathogenic bacteria of humans, suggesting that DT104 in animals and humans should demonstrate similar prevalences of resistance determinants. Until very recently, only the application of molecular methods would allow such a comparison and our understanding has been hindered by the fact that surveillance data are primarily phenotypic in nature. Here, using large scale surveillance datasets and a novel Bayesian approach, we infer and compare the prevalence of Salmonella Genomic Island 1 (SGI1), SGI1 variants, and resistance determinants independent of SGI1 in animal and human DT104 isolates from such phenotypic data. We demonstrate differences in the prevalences of SGI1, SGI1-B, SGI1-C, absence of SGI1, and tetracycline resistance determinants independent of SGI1 between these human and animal populations, a finding that challenges established tenets that DT104 in domestic animals and humans are from the same well-mixed microbial population.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Haydon, Professor Daniel and Mellor, Professor Dominic and Denwood, Dr Matthew and Matthews, Professor Louise and Reid, Professor Stuart
• Authors: Mather, A.E., Denwood, M.J., Haydon, D.T., Matthews, L., Mellor, D.J., Coia, J.E., Brown, D.J., and Reid, S.W.J.
• College/School: College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing; College of Medical Veterinary and Life Sciences > School of Biodiversity, One Health & Veterinary Medicine
• Journal Name: PLoS ONE
• Publisher: Public Library of Science
• ISSN: 1932-6203
• ISSN (Online): 1932-6203
• Published Online: 18 November 2011
• Copyright Holders: Copyright © 2011 The Authors
• First Published: First published in PLoS ONE 6(11):e27220
• Publisher Policy: Reproduced in accordance with the copyright policy of the publisher