Günther, S., Storm, J. and Muller, S. (2009) Plasmodium falciparum : organelle-specific acquisition of lipoic acid. International Journal of Biochemistry and Cell Biology, 41(4), pp. 748-752. (doi: 10.1016/j.biocel.2008.10.028)
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Publisher's URL: http://dx.doi.org/10.1016/j.biocel.2008.10.028
Abstract
Lipoic acid is an essential cofactor of multienzyme complexes that are integral to energy metabolism, amino acid degradation and folate metabolism. In recent years it has been shown that the malaria parasite <i>Plasmodium falciparum</i> possesses organelle-specific pathways that guarantee the lipoylation of their multienzyme complexes which occur in the mitochondrion (LA salvage) and in a plastid-like organelle, the apicoplast (LA biosynthesis). The unique distribution of the lipoylation machineries and the unique metabolic requirements of the parasites present a situation that is potentially exploitable for new ways to improve malaria control
| Item Type: | Articles |
|---|---|
| Keywords: | Malaria, Drug target, Apicoplast, Mitochondrion, Lipoylation |
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Muller, Professor Sylke and Storm, Dr Janet |
| Authors: | Günther, S., Storm, J., and Muller, S. |
| Subjects: | Q Science > QH Natural history > QH345 Biochemistry |
| College/School: | College of Medical Veterinary and Life Sciences College of Medical Veterinary and Life Sciences > School of Infection & Immunity |
| Journal Name: | International Journal of Biochemistry and Cell Biology |
| ISSN: | 1357-2725 |
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