Peripheral neuropathy associated with monoclonal IgM anti-Pr2 cold agglutinins

Willison, H.J. , Paterson, G., Veitch, J., Inglis, G. and Barnett, S.C. (1993) Peripheral neuropathy associated with monoclonal IgM anti-Pr2 cold agglutinins. Journal of Neurology, Neurosurgery and Psychiatry, 56(11), pp. 1178-1183. (doi: 10.1136/jnnp.56.11.1178)

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A patient with a chronic, large fibre sensory neuropathy had an immunoglobulin M lambda monoclonal paraprotein reactive at titres in excess of 1/10(5) with NeuNAc(α 2-8)NeuNAc(α 2-3)Gal configured disialosyl groups present on the gangliosides GD1b, GT1b, GQ1b, and GD3. The paraprotein showed weaker reactivity with GD1a, GM3, and LM1 but no reactivity with GM2, GM1, or asialo-GM1. In addition, the paraprotein had cold agglutinating activity with anti-Pr2 specificity, Pr2 being an antigenic determinant on membrane glycoproteins or glycolipids in erythrocytes or both. A large fibre sensory neuropathy with monoclonal anti-disialosyl antibodies is an increasingly recognised form of paraproteinaemic neuropathy.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Willison, Professor Hugh and Barnett, Professor Susan
Authors: Willison, H.J., Paterson, G., Veitch, J., Inglis, G., and Barnett, S.C.
College/School:College of Medical Veterinary and Life Sciences > School of Infection & Immunity
Journal Name:Journal of Neurology, Neurosurgery and Psychiatry
ISSN (Online):1468-330X

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