Monoclonal IgM cold agglutinins with anti-Pr1d specificity in a patient with peripheral neuropathy

Herron, B., Willison, H.J. , Veitch, J., Roelcke, D., Illis, L.S. and Boulton, F.E. (1994) Monoclonal IgM cold agglutinins with anti-Pr1d specificity in a patient with peripheral neuropathy. Vox Sanguinis, 67(1), pp. 58-63. (doi: 10.1111/j.1423-0410.1994.tb05039.x)

Full text not currently available from Enlighten.

Publisher's URL: http://dx.doi.org/10.1111/j.1423-0410.1994.tb05039.x

Abstract

A patient with a demyelinating sensory motor polyneuropathy secondary to IgM paraproteinaemia is reported. The paraprotein binds to the gangliosides GD1b, GT1b, GQ1b and GD3, all of which contain disialosyl groups with the sequence NeuAc α 2-8NeuAc α 2-3Gal. The paraprotein also acts as a cold agglutinin recognising the sialic-acid-dependent Pr<sub>1d</sub> antigenic determinant of the red cell membrane glycophorins. In this and in similar cases that have been reported, the coexistence of anti-Pr cold agglutinins and peripheral neuropathy suggest that they might be the causative agents of the disease.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Willison, Professor Hugh
Authors: Herron, B., Willison, H.J., Veitch, J., Roelcke, D., Illis, L.S., and Boulton, F.E.
College/School:College of Medical Veterinary and Life Sciences > School of Infection & Immunity
Journal Name:Vox Sanguinis
ISSN:0042-9007
ISSN (Online):1423-0410

University Staff: Request a correction | Enlighten Editors: Update this record