Ovarian cancer in elderly patients: carboplatin and pegylated liposomal doxorubicin versus carboplatin and paclitaxel in late relapse: a Gynecologic Cancer Intergroup (GCIG) CALYPSO sub-study

Kurtz, J. E. et al. (2011) Ovarian cancer in elderly patients: carboplatin and pegylated liposomal doxorubicin versus carboplatin and paclitaxel in late relapse: a Gynecologic Cancer Intergroup (GCIG) CALYPSO sub-study. Annals of Oncology, 22(11), pp. 2417-2423. (doi: 10.1093/annonc/mdr001)

Abstract

Background: CALYPSO (CAeLYx in Platinum Sensitive Ovarian) patients compared carboplatin–pegylated liposomal doxorubicin (C–PLD) with carboplatin–paclitaxel (C–P) in patients with late-relapsing recurrent ovarian cancer (ROC). We analyzed outcomes in patients ≥70 years. Patients and methods: Nine hundred and seventy-six patients with taxane-pretreated ROC relapsing >6 months after first- or second-line platinum-based therapy were randomly assigned to 4-weekly C area under the curve (AUC) 5 plus PLD 30 mg/m2 or 3-weekly C AUC 5 plus P 175 mg/m2 for six or more cycles. Results: One hundred and fifty-seven (16%) patients ≥70 years (median: 74 years, C–PLD; 73 years, C–P; range 70–82 years) were included (n = 71, C–PLD; n = 86, C–P). In comparing elderly and younger, elderly patients experienced fewer grade ≥2 allergic reactions (P = 0.005) but more grade ≥2 sensory neuropathy (P  = 0.007). Myelosuppression did not differ with age. Elderly patients completed planned treatment as frequently as younger (79%, C–PLD; 82%, C–P). In comparing arms within elderly patients, C–P was associated with more grade ≥2 alopecia, sensory neuropathy, arthralgia/myalgia (P <0.001 for all), severe leukopenia plus febrile neutropenia; C–PLD was associated with more grade ≥2 hand–foot syndrome (P = 0.005). Median progression-free survival was 11.6 months (C–PLD) and 10.3 months (C–P; P = 0.44). Conclusions: Patients ≥70 years experienced more neuropathy, with a higher incidence in the C–P arm. Similar to all study patients, C–PLD provided a better therapeutic index with less toxicity than C–P in elderly women with platinum-sensitive ROC.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Reed, Dr Nicholas
• Authors: Kurtz, J. E., Kaminsky, M. C., Floquet, A., Veillard, A. S., Kimmig, R., Dorum, A., Elit, L., Buck, M., Petru, E., Reed, N., Scambia, G., Varsellona, N., Brown, C., and Pujade-Lauraine, E.
• College/School: College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
• Journal Name: Annals of Oncology
• Journal Abbr.: Ann Oncol
• Publisher: Oxford University Press (OUP)
• ISSN: 0923-7534
• ISSN (Online): 1569-8041
• Published Online: 14 March 2011