Inflammation-associated graft loss in renal transplant recipients

Dahle, D. O. et al. (2011) Inflammation-associated graft loss in renal transplant recipients. Nephrology Dialysis Transplantation, 26(11), pp. 3756-3761. (doi: 10.1093/ndt/gfr163)

Abstract

<p><b>Background:</b> Although short-term graft survival has improved substantially in renal transplant recipients, long-term graft survival has not improved over the last decades. The lack of knowledge of specific causes and risk factors has hampered improvements in long-term allograft survival. There is an uncertainty if inflammation is associated with late graft loss.</p> <p><b>Methods:</b> We examined, in a large prospective trial, the inflammation markers high-sensitivity C-reactive protein (hsCRP) and interleukin-6 (IL-6) and their association with chronic graft dysfunction. We collected data from the Assessment of Lescol in Renal Transplant trial, which recruited 2102 maintenance renal transplant recipients.</p> <p><b>Results:</b> Baseline values were hsCRP 3.8 +/- 6.7 mg/L and IL-6 2.9 +/- 1.9 pg/mL. Adjusted for traditional risk factors, hsCRP and IL-6 were independently associated with death-censored graft loss, the composite end points graft loss or death and doubling of serum creatinine, graft loss or death.</p> <p><b>Conclusion:</b> The inflammation markers hsCRP and IL-6 are associated with long-term graft outcomes in renal transplant recipients.</p>

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Jardine, Professor Alan
• Authors: Dahle, D. O., Mjoen, G., Oqvist, B., Scharnagl, H., Weihrauch, G., Grammer, T., Marz, W., Abedini, S., Norby, G. E., Holme, I., Fellstrom, B., Jardine, A.G., and Holdaas, H.
• Subjects: R Medicine > RC Internal medicine
• College/School: College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health
• Journal Name: Nephrology Dialysis Transplantation
• Publisher: Oxford University Press
• ISSN: 0931-0509
• ISSN (Online): 1460-2385