Pathological gambling in Parkinson's disease - a review of the literature

Djamshidian, A., Cardoso, F., Grosset, D. , Bowden-Jones, H. and Lees, A.J. (2011) Pathological gambling in Parkinson's disease - a review of the literature. Movement Disorders, 26(11), pp. 1976-1984. (doi: 10.1002/mds.23821)

Abstract

The prevalence of pathological gambling is 3.4% to 6% in treated Parkinson's disease, which is higher than the background population rate. In this review we discuss current evidence to indicate that dopamine agonists are much more likely to trigger this behavior than either L-dopa or selective monoamine oxidase B inhibitor monotherapy. New insights from recent behavioral and functional imaging studies and possible treatment approaches are also covered. A PubMed literature search using the terms "gambling" and "Parkin-son's disease," "impulse control disorder," "impulsive compulsive behaviour," "dopamine agonist," of individual dopamine agonists, and of ongoing drug trials, using <a href="http://www.clinicaltrials.gov/">www.clinicaltrials.gov</a> was carried out for the period up to January 2011.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Grosset, Professor Donald
• Authors: Djamshidian, A., Cardoso, F., Grosset, D., Bowden-Jones, H., and Lees, A.J.
• Subjects: R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
• College/School: College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
• Journal Name: Movement Disorders
• Publisher: Wiley-Blackwell
• ISSN: 0885-3185
• Published Online: 09 June 2011