Spatial control of cAMP signalling in health and disease

Zaccolo, M. (2012) Spatial control of cAMP signalling in health and disease. Current Opinion in Pharmacology, 11(6), pp. 649-655. (doi: 10.1016/j.coph.2011.09.014)

Abstract

The cyclic adenosine 3',5' -monophosphate signalling pathway is now recognised to transduce signals in a compartmentalised manner such that individual stimuli only engage a subset of the pathway components that are physically constrained within defined subcellular locales, thus resulting in a precise functional outcome. As we are starting to appreciate the complexity of the spatial organisation and of the temporal regulation of this pathway, it is becoming clear that disruption of local signalling may lead to pathology and that local manipulation of cAMP signals may offer alternative approaches to treat disease.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Zaccolo, Professor Manuela
• Authors: Zaccolo, M.
• Subjects: R Medicine > RM Therapeutics. Pharmacology
• College/School: College of Medical Veterinary and Life Sciences > School of Psychology & Neuroscience
• Journal Name: Current Opinion in Pharmacology
• ISSN: 1471-4892