Bain, C.C. and Mowat, A.M. (2011) Intestinal macrophages - specialised adaptation to a unique environment. European Journal of Immunology, 41(9), pp. 2494-2498. (doi: 10.1002/eji.201141714)
Full text not currently available from Enlighten.
Publisher's URL: http://dx.doi.org/10.1002/eji.201141714
Abstract
Interest in intestinal mononuclear phagocytes (MPs), both DCs and macrophages (M phi s), has exploded in the recent years. In this Viewpoint we will detail how resident intestinal lamina propria (LP) M phi s possess distinctive properties that reflect adaptation to a unique microenvironment. They play quite different roles in the normal and inflamed mucosa and, as we will show, the existing paradigms of differentiated M phi subsets and of 'resident' versus 'inflammatory' monocytes based on other tissues may not apply to the gut. Strategies for targeting M phi s as a means of dampening intestinal inflammation will need to take account of these unique characteristics
Item Type: | Articles |
---|---|
Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Mowat, Professor Allan |
Authors: | Bain, C.C., and Mowat, A.M. |
College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity |
Journal Name: | European Journal of Immunology |
ISSN: | 0014-2980 |
University Staff: Request a correction | Enlighten Editors: Update this record