Stevens, K.K., McQuarrie, E.P., Sands, W., Hillyard, D.Z., Patel, R.K., Mark, P.B. and Jardine, A.G. (2011) Fibroblast growth factor 23 predicts left ventricular mass and induces cell adhesion molecule formation. International Journal of Nephrology, 2011(297070), pp. 1-6. (doi: 10.4061/2011/297070)
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Publisher's URL: http://dx.doi.org/10.4061/2011/297070
Abstract
Elevated FGF-23 is a predictor of mortality and is associated with LVH in CKD. It may be a biomarker or a direct toxin. We assessed the relationship between FGF-23 and LVH in CKD using CMRI. In vitro we studied the effect of phosphate, FGF-23, and Klotho on E-selectin and VCAM production in HUVECs. FGF-23 concentration correlates negatively with eGFR and positively with LVMI. FGF-23 was an independent predictor of LVH in CKD. E-selectin and VCAM production was elevated in HUVECs cultured in high phosphate with FGF-23 or Klotho. This effect was attenuated in cells exposed to both FGF-23 and Klotho. FGF-23 is an independent predictor of LVH as measured by CMRI. We show preliminary data which supports that FGF-23 is toxic resulting in activation of the vascular endothelium. We do not prove causality with elevated FGF-23 and LVH. Further research should ascertain if lowering levels of FGF-23 translates to improved clinical outcomes.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Patel, Dr Rajan and McQuarrie, Dr Emily and Stevens, Dr Kathryn and Mark, Professor Patrick and Sands, Dr William and Hillyard, Ms Dianne and Jardine, Professor Alan |
| Authors: | Stevens, K.K., McQuarrie, E.P., Sands, W., Hillyard, D.Z., Patel, R.K., Mark, P.B., and Jardine, A.G. |
| Subjects: | R Medicine > RC Internal medicine |
| College/School: | College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health College of Medical Veterinary and Life Sciences > School of Cancer Sciences |
| Journal Name: | International Journal of Nephrology |
| ISSN: | 2090-2158 |
| Related URLs: |
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