Dose-dense and dose-intense chemotherapy for small cell ovarian cancer: 2 cases and review of literature

Shrimali, R.K., Correa, P.D. and Reed, N.S. (2011) Dose-dense and dose-intense chemotherapy for small cell ovarian cancer: 2 cases and review of literature. Medical Oncology, 28(3), pp. 766-770. (doi: 10.1007/s12032-010-9509-0)

Full text not currently available from Enlighten.


Small cell carcinomas of the ovary (SCCO) are rare and aggressive malignant neoplasms carrying a poor prognosis. Although multi-modality treatment including chemotherapy leads to a high initial response rate, the majority of these patients relapse quickly and die within 2 years of diagnosis. Because these tumours are rare, there is no consensus to support any particular approach to management. We present 2 cases and review the relevant literature to make a number of recommendations. The treatment of these unusual cases should to be individually discussed in a multi-disciplinary team and multi-modality treatment including surgery, chemotherapy and radiotherapy should be considered for patients with limited disease. Conservative, fertility-preserving surgery may be considered in younger women with early-stage disease. Induction chemotherapy with weekly dose-dense and dose-intense carboplatin and taxane is useful. Prophylactic cranial irradiation (PCI) may be considered in patients in remission after primary treatment with chemotherapy or surgery.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Reed, Dr Nicholas
Authors: Shrimali, R.K., Correa, P.D., and Reed, N.S.
Subjects:R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
College/School:College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
Journal Name:Medical Oncology
Published Online:02 April 2010

University Staff: Request a correction | Enlighten Editors: Update this record