McEwan, W. A., McMonagle, E. L., Logan, N., Serra, R. C., Kat, P., Vandewoude, S., Hosie, M. J. and Willett, B. J. (2008) Genetically divergent strains of feline immunodeficiency virus from the domestic cat (Felis catus) and the African lion (Panthera leo) share usage of CD134 and CXCR4 as entry receptors. Journal of Virology, 82(21), pp. 10953-10958. (doi: 10.1128/JVI.01312-08)
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Publisher's URL: http://dx.doi.org/10.1128/JVI.01312-08
Abstract
The <i>env</i> open reading frames of African lion (<i>Panthera leo</i>) lentivirus (feline immunodeficiency virus [FIV(<sub>Ple</sub>)]) subtypes B and E from geographically distinct regions of Africa suggest two distinct ancestries, with FIV(<sub>Ple</sub>)-E sharing a common ancestor with the domestic cat (<i>Felis catus</i>) lentivirus (FIV(<sub>Fca</sub>)). Here we demonstrate that FIV(<sub>Ple</sub>)-E and FIV(<sub>Fca</sub>) share the use of CD134 (OX40) and CXCR4 as a primary receptor and coreceptor, respectively, and that both lion CD134 and CXCR4 are functional receptors for FIV(<sub>Ple</sub>)-E. The shared usage of CD134 and CXCR4 by FIV(<sub>Fca</sub>) and FIV(<sub>Ple</sub>)-E may have implications for in vivo cell tropism and the pathogenicity of the E subtype among free-ranging lion populations.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Hosie, Professor Margaret and Willett, Professor Brian and McMonagle, Mrs Linda and Logan, Miss Nicola |
Authors: | McEwan, W. A., McMonagle, E. L., Logan, N., Serra, R. C., Kat, P., Vandewoude, S., Hosie, M. J., and Willett, B. J. |
Subjects: | Q Science > QL Zoology Q Science > QR Microbiology > QR355 Virology |
College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity College of Medical Veterinary and Life Sciences > School of Infection & Immunity > Centre for Virus Research |
Journal Name: | Journal of Virology |
Journal Abbr.: | J. Virol. |
Publisher: | American Society for Microbiology |
ISSN: | 0022-538X |
ISSN (Online): | 1098-5514 |
Published Online: | 20 August 2008 |
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