Arresting times for PTEN

Houslay, M.D. (2011) Arresting times for PTEN. EMBO Journal, 30(13), pp. 2513-2515. (doi: 10.1038/emboj.2011.200)

Abstract

The tumour suppressor PTEN (phosphatase and tensin deleted on chromosome 10) is an important regulator of cell proliferation and migration. In this issue of The EMBO Journal, Lima-Fernandes and colleagues show that the universal signalling scaffold protein, beta-arrestin dynamically interacts with PTEN, through a phosphorylation-controlled switch. This protein-protein interaction profoundly influences the ability of PTEN to regulate both cell proliferation, through activation of its lipid phosphatase activity, and enhance cell migration by unblocking the inhibitory effect of the PTEN C2 domain and by recruiting activated ROCK into a beta-arrestin/PTEN 'signalosome'

• Item Type: Articles (Editorial)
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Houslay, Professor Miles
• Authors: Houslay, M.D.
• College/School: College of Medical Veterinary and Life Sciences > School of Psychology & Neuroscience
• Journal Name: EMBO Journal
• ISSN: 0261-4189