Intestinal CD103+ dendritic cells: master regulators of tolerance?

Scott, C. L., Aumeunier, A. M. and Mowat, A. M. (2011) Intestinal CD103+ dendritic cells: master regulators of tolerance? Trends in Immunology, 32(9), pp. 412-419. (doi: 10.1016/j.it.2011.06.003) (PMID:21816673)

Abstract

CD103+ dendritic cells (DCs) in the intestinal mucosa play a crucial role in tolerance to commensal bacteria and food antigens. These cells originate in the lamina propria (LP) and migrate to the mesenteric lymph nodes (MLNs), where they drive the differentiation of gut-homing FoxP3+ regulatory T cells by producing retinoic acid from dietary vitamin A. Local [`]conditioning' factors in the LP might also contribute to this tolerogenic profile of CD103+ DCs. Considerably less is understood about the generation of active immunity or inflammation in the intestinal mucosa. This might require alterations in pre-existing CD103+ DCs, arrival of new DCs, or the action of a distinct DC population. Here, we discuss our current knowledge of this as yet incompletely understood population

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Aumeunier, Dr Aude and Mowat, Professor Allan
• Authors: Scott, C. L., Aumeunier, A. M., and Mowat, A. M.
• College/School: College of Medical Veterinary and Life Sciences > School of Infection & Immunity; College of Medical Veterinary and Life Sciences > School of Infection & Immunity > Centre for Virus Research
• Journal Name: Trends in Immunology
• Publisher: Elsevier Ltd.
• ISSN: 1471-4906
• ISSN (Online): 1471-4981
• Published Online: 02 August 2011