Measurement of kidney perfusion by magnetic resonance imaging: comparison of MRI with arterial spin labeling to para-aminohippuric acid plasma clearance in male subjects with metabolic syndrome

Ritt, M., Janka, R., Schneider, M.P., Martirosian, P., Hornegger, J., Bautz, W., Uder, M. and Schmieder, R.E. (2010) Measurement of kidney perfusion by magnetic resonance imaging: comparison of MRI with arterial spin labeling to para-aminohippuric acid plasma clearance in male subjects with metabolic syndrome. Nephrology Dialysis Transplantation, 25(4), pp. 1126-1133. (doi: 10.1093/ndt/gfp639)

Abstract

<p>Background. Magnetic resonance imaging with arterial spin labeling (MRI–ASL) is a non-invasive approach to measure organ perfusion. We aimed to examine whether MRI–ASL kidney perfusion measurements are related to measurements of renal plasma flow (RPF) by para-aminohippuric acid (PAH) plasma clearance and whether changes of kidney perfusion in response to treatment with telmisartan can be detected by MRI–ASL.</p> <p>Methods. Twenty-four patients with metabolic syndrome and an estimated creatinine clearance according to Cockroft and Gault of ≥60 ml/min were included in the study. Kidney perfusion was assessed by MRI–ASL measurements of a single coronal kidney slice (with flow-sensitive alternating inversion recovery and true fast imaging with steady-state processing sequence) and by measurements of RPF using PAH plasma clearance before and after 2 weeks of treatment with the angiotensin receptor blocker telmisartan. All MRI–ASL examinations were performed on a 1.5 T scanner.</p> <p>Results. Two weeks of therapy with telmisartan led to a significant increase of RPF (from 313 ± 47 to 348 ± 69 ml/min/m, P = 0.007) and MRI–ASL kidney perfusion measurements (from 253 ± 20 to 268 ± 25 ml/min/100 g, P = 0.020). RPF measurements were related with MRI–ASL kidney perfusion measurements (r = 0.575, P < 0.001). Changes of RPF measurements and changes of MRI–ASL kidney perfusion measurements in response to treatment with telmisartan revealed a close relationship when expressed in absolute terms (r = 0.548, P = 0.015) and in percentage changes (r = 0.514, P = 0.025).</p> <p>Conclusions. Perfusion measurement of a single coronal kidney slice by MRI–ASL is able to approximate kidney perfusion and to approximate changes in kidney perfusion due to pharmacological intervention.</p>

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Schneider, Dr Markus
• Authors: Ritt, M., Janka, R., Schneider, M.P., Martirosian, P., Hornegger, J., Bautz, W., Uder, M., and Schmieder, R.E.
• College/School: College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health
• Journal Name: Nephrology Dialysis Transplantation
• Publisher: Oxford University Press
• ISSN: 0931-0509
• ISSN (Online): 1460-2385
• Published Online: 24 November 2009