Schlitt, A. et al. (2007) Phospholipid transfer protein in hemodialysis patients. American Journal of Nephrology, 27(2), pp. 138-143.
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Abstract
<p><b>INTRODUCTION:</b> Phospholipid transfer protein (PLTP) is mainly involved in high-density lipoprotein (HDL) metabolism. The role of PLTP in atherogenesis is still controversial. We aimed to investigate PLTP activity in hemodialysis (HD) patients, a population which has an increased risk for the development of atherosclerosis.</p> <p><b>METHODS:</b> PLTP activity and other markers were analyzed in blood samples from 68 HD patients and in a matched group of 68 healthy controls.</p> <p><b>RESULTS:</b> Serum PLTP activity was nearly doubled in HD patients in comparison to healthy controls (median 43.0 vs. 22.4 pmol/mul/h, p < 0.001). In HD patients, PLTP activity correlated with HDL-C (r = 0.342, p = 0.004), but not with CRP (r = -0.057, p = 0.644) or leukocyte count (r = 0.116, p = 0.345). After a follow-up of 2 years, 26 HD patients had died. Kaplan-Meier analyses showed that low CRP (p = 0.047) but neither high HDL-C (p = 0.071) nor low PLTP activity (p = 0.853) were relevantly related to survival of HD patients.</p> <p><b>CONCLUSION:</b> An elevated PLTP activity in HD patients may be considered as a further aspect of uremic dyslipidemia in HD patients. However, PLTP activity was not related to markers of inflammation or to survival of HD patients, even though it correlated with HDL-C. Thus, we conclude that PLTP does not influence the prognostically relevant inflammatory process in HD patients although it does influence the composition of HDL particles.</p>
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Messow, Dr Martina |
| Authors: | Schlitt, A., Heine, G.H., Jiang, X.C., Messow, C., Blankenberg, S., Rupprecht, H.J., Ulrich, C., Buerke, M., Werdan, K., Lackner, K.J., Kohler, H., and Girndt, M. |
| Subjects: | R Medicine > R Medicine (General) |
| College/School: | College of Medical Veterinary and Life Sciences > School of Health & Wellbeing > Robertson Centre ?? 20206000 ?? |
| Journal Name: | American Journal of Nephrology |
| Publisher: | S. Karger AG |
| ISSN: | 0250-8095 |
| ISSN (Online): | 1421-9670 |
| Published Online: | 16 February 2007 |
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