Wang, D. et al. (2011) Identification of bacterial target proteins for the salicylidene acylhydrazide class of virulence blocking compounds. Journal of Biological Chemistry, 286(34), pp. 29922-29931. (doi: 10.1074/jbc.M111.233858) (PMID:21724850) (PMCID:PMC3191033)
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Abstract
A class of anti-virulence compounds, the salicylidene acylhydrazides, have been widely reported to block the function of the type three secretion system of several Gram-negative pathogens by a previously unknown mechanism. In this work, we provide the first identification of bacterial proteins that are targeted by this group of compounds. We provide evidence that their mode of action is likely to result from a synergistic effect arising from a perturbation of the function of several conserved proteins. We also examine the contribution of selected target proteins to the pathogenicity of Yersina pseudotuberculosis and to expression of virulence genes in Escherichia coli O157.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Wang, Mr Dai and Gabrielsen, Dr Mads and Roe, Professor Andrew and Burchmore, Dr Richard and Herzyk, Dr Pawel and Smith, Dr Brian and Byron, Professor Olwyn and Mitchell, Professor Timothy |
| Authors: | Wang, D., Zetterstrom, C.E., Gabrielsen, M., Beckham, K.S.H., Tree, J.J., Macdonald, S.E., Byron, O., Mitchell, T.J., Gally, D.L., Herzyk, P., Mahajan, A., Uvell, H., Burchmore, R., Smith, B.O., Elofsson, M., and Roe, A.J. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity College of Medical Veterinary and Life Sciences > School of Molecular Biosciences College of Medical Veterinary and Life Sciences > School of Life Sciences |
| Journal Name: | Journal of Biological Chemistry |
| Journal Abbr.: | J Biol Chem. |
| Publisher: | American Society for Biochemistry and Molecular Biology, Inc. |
| ISSN: | 0021-9258 |
| ISSN (Online): | 1083-351X |
| Published Online: | 01 July 2011 |
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