Fowler, L.S., Thomas, L.H., Ellis, D. and Sutherland, A. (2011) A one-pot reductive amination/6-endo-trig cyclisation for the stereoselective synthesis of 6-substituted-4-oxopipecolic acids. Chemical Communications, 47(23), pp. 6569-6571. (doi: 10.1039/c1cc11916h)
Full text not currently available from Enlighten.
Publisher's URL: http://dx.doi.org/10.1039/C1CC11916H
Abstract
The first stereoselective synthesis of 2,6-<i>trans</i>-6-substituted-4-oxo-L-pipecolic acids using a tandem reductive amination/6-<i>endo-trig</i> cyclisation process is described. The sequential reduction and cyclisation mediated by sodium cyanoborohydride allowed the preparation of a series of highly functionalised 6-alkyl and 6-aryl analogues.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Thomas, Dr Lynne and Sutherland, Professor Andrew |
| Authors: | Fowler, L.S., Thomas, L.H., Ellis, D., and Sutherland, A. |
| Subjects: | Q Science > QD Chemistry |
| College/School: | College of Science and Engineering > School of Chemistry |
| Journal Name: | Chemical Communications |
| Journal Abbr.: | Chem. Comm. |
| ISSN: | 1359-7345 |
| ISSN (Online): | 1364-548X |
| Related URLs: |
University Staff: Request a correction | Enlighten Editors: Update this record
Altmetric
Altmetric