Figlus, M., Wellaway, N., Cooper, A.W.J., Sollis, S.L. and Hartley, R.C. (2011) Synthesis of arrays using low molecular weight MPEG-assisted Mitsunobu reaction. ACS Combinatorial Science, 13(3), pp. 280-285. (doi: 10.1021/co100091n)
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Publisher's URL: http://dx.doi.org/10.1021/co100091n
Abstract
Triphenylphosphine tagged with a short poly-(ethyleneglycol)-ω-monomethyl ether chain (light MPEG, 10−16 ethylenoxy units, (M)TPP-G2) and an MPEG-tagged version of diethyl azodicarboxylate ((M)DEAD) have been used to prepare a 20 member library of esters, ethers, and sulfonamides, with cLogP's in the range of 1.4−5.7 on a 0.1 mmol scale. Removal of MPEG-tagged side products was achieved by MPEG-assisted solid-phase extraction (MSPE) on prepacked silica columns to give the products in good yield and high purity.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Hartley, Professor Richard and Figlus, Mr Marek |
| Authors: | Figlus, M., Wellaway, N., Cooper, A.W.J., Sollis, S.L., and Hartley, R.C. |
| College/School: | College of Science and Engineering > School of Chemistry |
| Journal Name: | ACS Combinatorial Science |
| Publisher: | ACS Publications |
| ISSN: | 2156-8952 |
| ISSN (Online): | 1520-4774 |
| Published Online: | 25 March 2011 |
| Related URLs: |
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