Neilson, M.P., Mackenzie, J.A., Webb, S.D. and Insall, R.H. (2011) Modeling Cell Movement and Chemotaxis Using Pseudopod-Based Feedback. SIAM Journal on Scientific Computing, 33(3), pp. 1035-1057. (doi: 10.1137/100788938)
Full text not currently available from Enlighten.
Publisher's URL: http://dx.doi.org/10.1137/100788938
Abstract
A computational framework is presented for the simulation of eukaryotic cell migration and chemotaxis. An empirical pattern formation model, based on a system of nonlinear reaction-diffusion equations, is approximated on an evolving cell boundary using an arbitrary Lagrangian Eulerian surface finite element method (ALE-SFEM). The solution state is used to drive a mechanical model of the protrusive and retractive forces exerted on the cell boundary. Movement of the cell is achieved using a level set method. Results are presented for cell migration with and without chemotaxis. The simulated behavior is compared with experimental results of migrating Dictyostelium discoideum cells
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Neilson, Dr Matthew and Insall, Professor Robert |
| Authors: | Neilson, M.P., Mackenzie, J.A., Webb, S.D., and Insall, R.H. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Cancer Sciences |
| Journal Name: | SIAM Journal on Scientific Computing |
| Publisher: | Society for Industrial and Applied Mathematics |
| ISSN: | 1064-8275 |
| ISSN (Online): | 1095-7197 |
| Published Online: | 05 May 2011 |
University Staff: Request a correction | Enlighten Editors: Update this record
Altmetric
Altmetric