Efficacy of ivabradine, a new selective If inhibitor, compared with atenolol in patients with chronic stable angina

Tardif, J.-C., Ford, I. , Tendera, M., Bourassa, M.G. and Fox, K. (2005) Efficacy of ivabradine, a new selective If inhibitor, compared with atenolol in patients with chronic stable angina. European Heart Journal, 26(23), pp. 2529-2536. (doi: 10.1093/eurheartj/ehi586)

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<p>Aims: Ivabradine, a new I<sub>f</sub> inhibitor which acts specifically on the pacemaker activity of the sinoatrial node, is a pure heart rate lowering agent. Ivabradine has shown anti-ischaemic and anti-anginal activity in a placebo-controlled trial. The objective of this study was to compare the anti-anginal and anti-ischaemic effects of ivabradine and the beta-blocker atenolol.</p> <p>Methods and results: In a double-blinded trial, 939 patients with stable angina were randomized to receive ivabradine 5 mg bid for 4 weeks and then either 7.5 or 10 mg bid for 12 weeks or atenolol 50 mg od for 4 weeks and then 100 mg od for 12 weeks. Patients underwent treadmill exercise tests at randomization (M0) and after 4 (M1) and 16 (M4) weeks of therapy. Increases in total exercise duration (TED) at trough at M4 were 86.8±129.0 and 91.7±118.8 s with ivabradine 7.5 and 10 mg, respectively and 78.8±133.4 s with atenolol 100 mg. Mean differences (SE) when compared with atenolol 100 mg were 10.3 (9.4) and 15.7 (9.5) s in favour of ivabradine 7.5 and 10 mg (P<0.001 for non-inferiority). TED at M1 improved by 64.2±104.0 s with ivabradine 5 mg and by 60.0±114.4 s with atenolol 50 mg (P<0.001 for non-inferiority). Non-inferiority of ivabradine was shown at all doses and for all criteria. The number of angina attacks was decreased by two-thirds with both ivabradine and atenolol.</p> <p>Conclusion: Ivabradine is as effective as atenolol in patients with stable angina.</p>

Item Type:Articles (Editorial)
Glasgow Author(s) Enlighten ID:Ford, Professor Ian
Authors: Tardif, J.-C., Ford, I., Tendera, M., Bourassa, M.G., and Fox, K.
Subjects:R Medicine > R Medicine (General)
College/School:College of Medical Veterinary and Life Sciences > School of Health & Wellbeing > Robertson Centre
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Research Group:INITIATIVE Investigators
Journal Name:European Heart Journal
ISSN (Online):1522-9645
Published Online:07 October 2005

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