Improving blood pressure control in patients with diabetes mellitus and high cardiovascular risk

Elliot, H.L., Lloyd, S.M. , Ford, I. and Meredith, P.A. (2010) Improving blood pressure control in patients with diabetes mellitus and high cardiovascular risk. International Journal of Hypertension, 2010(Articl), (doi: 10.4061/2010/490769)

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Patients with diabetes mellitus and symptomatic coronary artery disease are also likely to be hypertensive and, overall, are at very high cardiovascular (CV) risk. This paper reports the findings of a posthoc analysis of the 1113 patients with diabetes mellitus in the ACTION trial: ACTION itself showed that outcomes in patients with stable angina and hypertension were significantly improved when a long-acting calcium channel blocking drug (nifedipine GITS) was added to their treatment regimens. This further analysis of the ACTION database in those patients with diabetes has identified a number of practical therapeutic issues which are still relevant because of potential outcome benefits, particularly in relation to BP control. For example, despite background CV treatment and, specifically, despite the widespread use of ACE Inhibitor drugs, the addition of nifedipine GITS was associated with significant benefits: improvement in BP control by an average of 6/3 mmHg and significant improvements in outcome. In summary, this retrospective analysis has identified that the addition of nifedipine GITS resulted in improved BP control and significant outcome benefits in patients with diabetes who were at high CV risk. There is evidence to suggest that these findings are of direct relevance to current therapeutic practice.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Meredith, Dr Peter and Lloyd, Miss Suzanne and Ford, Professor Ian
Authors: Elliot, H.L., Lloyd, S.M., Ford, I., and Meredith, P.A.
Subjects:R Medicine > R Medicine (General)
College/School:College of Medical Veterinary and Life Sciences > School of Health & Wellbeing > Robertson Centre
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Journal Name:International Journal of Hypertension
Publisher:SAGE-Hindawi Access to Research
ISSN (Online):2090-0392
Published Online:01 January 2010
Copyright Holders:Copyright © 2010 The Authors
First Published:First published in International Journal of Hypertension 2010:Article ID 490769
Publisher Policy:Reproduced with the permission of the authors

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