Homerova, D., Rezuchova, B., Stevenson, A., Skovierova, H., Roberts, M. and Kormanec, J. (2011) Characterization of the micA gene encoding a small regulatory σE-dependent RNA in Salmonella enterica serovar Typhimurium. Folia Microbiologica, 56(1), pp. 59-65. (doi: 10.1007/s12223-011-0014-4) (PMID:21394477)
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Publisher's URL: http://dx.doi.org/10.1007/s12223-011-0014-4
Abstract
The role of MicA (repressing small regulatory non-coding RNAs of two Salmonella porins) was determined in virulence of Salmonella enterica serovar Typhimurium. Transcriptional analysis revealed that the expression of the micA gene is driven by a single sigma(E)-dependent promoter, micAp. Its activity increased towards stationary phase; in exponential phase, the activity was induced by several stresses by a DegS-dependent mechanism. Although phenotypic analysis revealed no significant differences between wild-type and the micA mutant strains, in vivo studies showed that this mutant is more virulent in the mouse model
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Roberts, Professor Mark |
| Authors: | Homerova, D., Rezuchova, B., Stevenson, A., Skovierova, H., Roberts, M., and Kormanec, J. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Biodiversity, One Health & Veterinary Medicine |
| Journal Name: | Folia Microbiologica |
| ISSN: | 0015-5632 |
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