Proton beam radiotherapy in the management of uveal melanoma: clinical experience in Scotland

Aziz, S., Taylor, A., McConnachie, A. , Kacperek, A. and Kemp, E. (2009) Proton beam radiotherapy in the management of uveal melanoma: clinical experience in Scotland. Clinical Opthalmology, 3, pp. 49-55. (doi: 10.2147/OPTH.S3555)

Abstract

<p>Aim: To evaluate proton-beam radiotherapy (PBRT) in the management of uveal melanoma in Scotland.</p> <p>Methods: A retrospective review was undertaken on all patients receiving PBRT for uveal melanoma (1994–2005). Data obtained included: gender, past ocular/medical history, age, presenting complaint(s), diagnosis, laterality, tumor location/ultrasound characteristics, visual acuity (VA) and intraocular pressure. At post-treatment reviews (3, 6, 12, and 24 months), the following data was obtained: VA, intraocular pressure, tumor appearance and ultrasound characteristics. Mean follow up was 38.8 months.</p> <p>Results: Seventy-six patients were included. Mean age was 64 years; male to female ratio was 1.1:1. Ninety-seven percent demonstrated initial treatment response; 87% had successful control of tumor growth. Mean pre-treatment tumor height was 6.2 mm v.s. 4.8 mm post-irradiation (p < 0.001). Pre-irradiation VA was <3/60 in 18.5% compared with 74% post-irradiation (p < 0.0001). There was a statistically significant association between adverse events (enucleation, metastasis) and greater maximal basal tumor diameter. Eighteen eyes were enucleated. The median survival time was estimated to be 54 months.</p> <p>Conclusion: In our experience, PBRT is a precise, reliable and effective treatment in the management of large, and previously treated uveal melanomas. It prevents enucleation in the majority at short term follow-up.</p>

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: McConnachie, Professor Alex
• Authors: Aziz, S., Taylor, A., McConnachie, A., Kacperek, A., and Kemp, E.
• Subjects: R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
• College/School: College of Medical Veterinary and Life Sciences > School of Health & Wellbeing > Robertson Centre; ?? 20206000 ??
• Journal Name: Clinical Opthalmology
• Publisher: Dove Medical Press
• ISSN: 1177-5467
• ISSN (Online): 1177-5483
• Published Online: 02 June 2009
• Copyright Holders: Copyright © 2009 The Authors and Dove Medical Press Ltd
• First Published: First published in Clinical Opthalmology 3:49-55
• Publisher Policy: Reproduced in accordance with the copyright policy of the publisher

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